The study of T cells, IgA, IgG and other immune function situations in patients with chronic obstructive pulmonary disease

Abstract

Objective To observe the changes of peripheral blood CD3,CD4,CD8 and CD4/CD8 and IgA,IgG in immune function of patients with chronic obstructive pulmonary disease (COPD).To understand COPD patients with immune dysfunction cases,provide a theoretical basis for the treatment of patients with COPD.Methods Seventy-six patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and 65 COPD cases in stable situation were selected in January 2013-November 2013.Serum CD3,CD4,CD8 and CD4/CD8 and IgA,IgG were determined.Sixty-eight routine healthy examination cases at the same period were selected as a control group.The test results of the three groups were compared respectively.Results Compared with the healthy control group,the CD3,CD4,CD4/CD8 and IgA decreased significantly (P ＜ 0.05) in both AECOPD and stable COPD groups.Compared with the stable COPD group,the CD3,CD4,CD4/CD8 and IgA also declined in AECOPD group,but showed no statistical difference (P ＞ 0.05).Conclusions The immune function was disordered and declined in COPD patients,especially in the AECOPD cases.In the clinical treatment of patients with COPD,in addition to anti-infection,anti-cough,expectorant,antispasmodic,antiasthma tic and other conventional treatment,while appropriate regulation of immune function,and other improved interventions were also needed,so that the condition of patients with COPD could improve as soon as possible,and finally achieved good therapeutic effect. Key words: Chronic obstructive pulmonary disease; Immune function; Clinical research