Expressions of serum TSLP, SAA, and CRP in COPD patients

Abstract

Objective To value different stages of chronic obstructive pulmonary disease (COPD) patients with the detection of the levels of serum thymic stromal lymphopoietin (TSLP), serum amyloid A (SAA), and C-reactive protein (CRP). Methods A total of 33 patients with COPD during and after hospitalization and 16 healthy controls were enrolled in the study from the 3rd affiliated hospital of SYSU. Differences and correlations of the level of serum TSLP, SAA and CRP were analyzed to value the veracity of those factors in different stages of COPD. Results The levels of CRP and SAA were higher in acute exacerbation of COPD (AECOPD) group than stable COPD group, TSLP was lower in the AECOPD group than the healthy control group (P<0.05). CRP had a positive correlation with SAA (correlation r=0.546, P=0.000), CRP [area under curve (AUC) =0.797] and SAA (AUC=0.815), and they were statistically significant in identity of different stages of COPD (P<0.05). Conclusions Serum TSLP level is decreased in acute exacerbation phase of COPD. CRP and SAA are increased in AECOPD. SAA is more confident in identity of different phases of COPD. Key words: Lymphopoiesis; Thymus gland/CY/ME; Serum amyloid A protein/ME; C-reactive protein/ME; Pulmonary disease, chronic obstructive/ME