The study of role of aspirin and antioxidants in prevention of hypertensive disorders in primigravidas

Abstract

Aim: To observe the effect of aspirin and other antioxidants in prevention of hypertension and there by the outcome of pregnancy in terms of maternal and perinatal morbidity and mortality.Material and Method: This is a prospective randomized controlled study carried out at OBGY department in NHL Municipal Medical College on 80 women attending antenatal OPD.Results: Gestational hypertension occurred in 5% of the case group while in 10% of the control group. Incidence of preeclampsia is nil in case group while its 5% in control group.Mean arterial Blood pressure both systolic and diastolic are less in case group compared to the control group.Incidence of oligohydroamnios is 2.5% in case group while 10% in control group, indicating the role of aspirin and antioxidants in prevention of oligohydroamnios.Incidence of meconium staining of liquor is nil in case group while it is 7.5% in the control group indicating the preventive role of low dose aspirin and antioxidants against MSL.Incidence of low birth weight babies is nil in case group while it is 25% in control group and Mean birth weight is 2.96 Kg in case group while 2.63 kg in control group indicating the importance of aspirin and antioxidants in preventing low birth weight babiesConclusion: It was noted in the present study that low dose aspirin and antioxidants may have beneficial effect in the prevention of hypertensive disorders of pregnancy in the high risk primigravida subjects.