Abstract
At the Department of Industrial Technology of Drugs suppositories for the treatment of degenerative and inflammatory diseases of the rectum have been developed; the active substance with the reparative activity – diacamph is included in their composition. The crystallographic characteristics of the diacamph original powder crystals, crushed diacamph crystals and suspensions of diacamph in propylene glycol have been studied. The optimal technology of diacamph introduction to the dosage form has been selected. Based on the thermogravimetric analysis the maximum heating temperature of the suppository mass has been determined, and the absence of interaction between the active substance and excipients in this dosage form has been proven. The research results will be used when developing the industrial technology for manufacturing suppositories.
Highlights
Proctology diseases remain an urgent problem of modern medicine due to the prevalence of destructive inflammatory processes in the rectum and the complexity of the course of pharmacotherapy of these pathologies [7, 9,10,11,12]
The visual examination under a microscope allows to observe the shape and structure of particles to obtain the preliminary data concerning their maximal and minimal sizes, and it is especially important when developing the technology of new dosage forms [3,4]
Taking into account that diacamph is in the suppository base as a suspension we conducted the study in order to select the rational technology of its introduction into the composition of suppositories
Summary
Proctology diseases remain an urgent problem of modern medicine due to the prevalence of destructive inflammatory processes in the rectum and the complexity of the course of pharmacotherapy of these pathologies [7, 9,10,11,12]. Taking into account that the range of domestic medicines for treating diseases of the rectum is insufficient there is a need to create new drugs in the most rational and effective dosage form in proctology – suppositories [8]. Taking into account that diseases of the rectum are accompanied by inflammatory and destructive processes the use of diacamph in proctology is appropriate. At the Department of Industrial Technology of Drugs of the National University of Pharmacy a new drug in the form of rectal suppositories with diacamph as an active substance has been developed [6]. The aim of this work is to study the crystallographic and thermogravimetric characteristics of the active substance and the full composition of suppositories for selecting the rational conditions of the technological process
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