Abstract
Crude methanolic and hexane extracts of seeds of citrullus colocynthis were examined for antimicrobial effects of different concentrations ranging from (3.1- 50) mg/ml against Staphylococcus aureus, Streptococcus pyogenes, Listeria monocytogenes, Bacillus subtilis, Proteus vulgaris, Escherichia coli, Klebsiella pneumoniae, Psendomonas aeruginosa, Salmonella typhi, Entero coccus spp. and Candida albicans. The agar well diffusion methode was used in this study.The extract was found to be active against S.aureus, B.subtilis, P. vulgaris, K. pneumoniae, and PS. aeruginosa at concentrations of (50, 25, 12.5, 6.25) mg/ml.while S. pyogenes and L.monocytogenes were sensitie at (50, 25, 12.5) mg/ml. E. coli shown sensitivity at (50, 25)mg/ml. Enterococcus spp. and Salmonella typhi showed no response. Candida albicans was sensitive to all different concentrations. Hexane extract was less effective against the tested microorganisms than methanolic extract. The results support the notion that Citrullus colocynthis seeds extract may have a role in pharmacentical uses, like antimicrobial drugs.
Highlights
During the last two decades, the development of drug resistance as well as the appearance of undesirable side effects of certain antibiotics [1,2] has lead to the search of new antimicrobial agents mainly among plant extracts with the goal toKey wordsCitrullus colocynthis, methanolic extract, antimicrobial activity انفعانٍت انًضاد ة نهبكخزٌا، ً انًضخخهص انًٍثاَىن، انحُظم:يفخاح انكهًاثdiscover new chemical structures which overcome the above disadvantages [3,4]
Candida albicans was sensitive to all different concentrations
Test microorganisms: All microbial strains used in the study were clinical strains,from health centers laboratories they were Staphylococcus aureus, Streptococcus pyogenes, Listeria monocytogenes, Bacillus subtilis, Proteus vulgaris, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Enterococcus spp. and Candida albicans
Summary
During the last two decades, the development of drug resistance as well as the appearance of undesirable side effects of certain antibiotics [1,2] has lead to the search of new antimicrobial agents mainly among plant extracts with the goal toKey wordsCitrullus colocynthis, methanolic extract, antimicrobial activity انفعانٍت انًضاد ة نهبكخزٌا، ً انًضخخهص انًٍثاَىن، انحُظم:يفخاح انكهًاثdiscover new chemical structures which overcome the above disadvantages [3,4]. Citrullus colocynthis seeds extract may have a role in pharmacentical uses, like antimicrobial drugs. Bacillus subtilis, Proteus vulgaris, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterococcus sp, Salmonella Key wordsCitrullus colocynthis, methanolic extract, antimicrobial activity انفعانٍت انًضاد ة نهبكخزٌا، ً انًضخخهص انًٍثاَىن، انحُظم:يفخاح انكهًاث
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