Abstract
Melanin-concentrating hormone 1 receptor (MCH1-R) mediates the orexigenic effects of melanin-concentrating hormone and its antagonists are considered as potential targets for the treatment of obesity. To design more potent and selective MCH1-R antagonists, at first, we built up the homology structure of MCH1-R. Then, we carried out the receptor based three dimensional Quantitative Structure Activity Relationship (3D-QSAR) using comparative molecular field analysis and Comparative Molecular Similarity Indices Analysis (CoMSIA) for a series of scaffold of MCH1-R antagonists and the docking study for MCH1-R. These models are proved as statistically valid models with a good correlative and predictive power. Based on these models, we are going to develop more potent and selective MCH1-R antagonists.
Published Version
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