Abstract
A primary Ca2+ entry pathway in non-excitable cells is determined by the Ca2+ release activated Ca2+ channels. Their two limiting molecular components include the Ca2+-sensor protein STIM1 located in the endoplasmic reticulum and the Orai channel in the plasma membrane. STIM1 senses the luminal Ca2+ content. Store depletion induces STIM1 oligomerization into puncta like structures, thereby triggering coupling to as well as activation of Orai1 channels. A C-terminal STIM1 domain couples to both N- and C-terminal, cytosolic strands of Orai, accomplishing gating of the channel. Here we highlight the inter- and intramolecular choreography of STIM1 and Orai proteins that govern in Ca2+ permeation.
Published Version
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