The State of Systemic and Local Immunity with Non ? Specific Vulvovaginitis in Adolescents

Abstract

The study showed that there is a secondary immune deficiency in the subacute course, and in acute immune deficiency it was not detected. In acute course compared with subacute one, there is an increased production of IFN-γ, which indicates the direct dependence of the pro-inflammatory cytokines activity level on the clinical course of the inflammatory process. A study of vaginal secretion phagocytosis revealed that in acute cases, the phagocytic function of the local secretion is satisfactory, while in the subacute case, satisfactory absorption function decreases the bactericidal activity of the vaginal secretion, which indicates the need for correction of the phagocytic link. The use of Roncoleukin parenterally in acute course does not affect normal immune status indicators, i.e. has a modulating effect depending on the initial immune status. In subacute case, local application leads to an increase in the absorption and oxygen-dependent bactericidal ability of the vaginal secretion, which contributes to the rapid regression of the clinical manifestations of vulvovaginitis, parenterally leading to normalization of the main indicators of the subpopulation composition of lymphocytes.