THE STATE OF NON-SPECIFIC RESISTANCE IN THE RESIDENTS OF MARIUPOL DURING THE WAR

Abstract

A study of indicators' state of non-specific resistance in conditionally healthy people of the Donetsk region, who lived in the city of Mariupol in the conditions of the ecological crisis during the Operation of the United Forces before the beginning of the invasion of the Russian Federation into Ukraine, was carried out. Immunological methods of the 1st level were used in the research. The state of non-specific resistance was assessed by the absolute content of peripheral blood leukocytes, content of neutrophils, eosinophils and monocytes. In addition, the frequency of detection in the examined individuals and the content in the neutrophils' pool of cells with: swollen, villous, hypersegmented, hyposegmented, fragmented nucleus, with toxogenic cytoplasmic granularity were determined. As a result of research, the activation of non-specific resistance was established in conditionally healthy residents of Mariupol, which was manifested by a significant and probable increase in the content of rod-shaped neutrophils, eosinophils, basophils and monocytes. Studies have documented a significant and likely increase in the frequency of detection of individuals with cytomorphologically altered neutrophils. In the neutrophil pool of residents of Mariupol, a significant and probable increase in the number of cellular breakdowns, the content of cells with swollen, hypersegmented, fragmented nuclei, villous chromatin of the nucleus and toxogenic granularity of the cytoplasm was established. The revealed cytomorphological changes reflected an increase in proportion of destroyed, degenerating cells compared to the proportion of functionally capable cells against the background of intoxication, mutagenic processes and increased lipid peroxidation. The results indicate a decrease in the stress of non-specific resistance with a tendency to failure of adaptation in conditionally healthy residents of the city of Mariupol before the beginning of the invasion of the Russian Federation into Ukraine on February 24, 2023. The obtained data is necessary as a reference point for monitoring and correcting the state of health of the city's residents after Ukraine's victory in the war with the Russian Federation.