The Stability of Self-inclusion Complexes of Cyclodextrin Derivatives Bearing a p-Dimethylaminobenze Moiety

Abstract

An appending moiety of modified cyclodextrins acts as an intramolecular guest and forms a self-inclusion complex in aqueous solution. In this study, the stability of self-inclusion complexes of modified cyclodextrins which have a p-dimethylaminobenzene moiety was analyzed by fluorescent decay analyses, and the factor that determines the stability of the self-inclusion complex was determined by a computational approach. The self-inclusion form is stabilized mainly due to van der Waals interaction between the appending moiety and the cyclodextrin ring.