Abstract
Unilateral lesions in and around the course of the nigrostriatal pathway (in the substantia nigra, in the supranigral region and more rostrally in the area of the medial forebrain bundle) in cats produced a marked slowing of single unit firing in the caudate nucleus contralateral to the lesion. In addition, the medial forebrain bundle lesion produced a tendency for an increase in unit firing rates in the caudate nucleus ipsilateral to the lesion. Lesions in the supranigral region in monkeys produced indications of a slowing in the firing rate of single units in the contralateral caudate and an increase in the firing rate of units in the caudate ipsilateral to the lesion. These alterations in spontaneous unit firing were independent of lesion-induced changes in concentrations of striatal dopamine or the activities of tyrosine hydroxylase and DOPA decarboxylase.
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