Abstract
A new, simple and sensitive spectrophotometric method was described for the determination of famotidine (FAM) as a pure material and in pharmaceutical formulation. This method was based on diazotization and coupling reaction between famotidine and diazotized solution of metochlopramide hydrochloride (DMPH) in the presence of phosphate buffer solution to give a compound of azo dye having orange color soluble in water with high absorptivity at a wave length of 478 nm. The data shows that FAM and DMPH combine in the molar ratio of 1:1 at PH 7.0 .The method obeys Beer's law over concentration range of 1-40 ?g.ml-1 of famotidine with a correlation coefficient of 0.9955 and a detection limit of 0.10 ?g.ml-1. The apparent molar absorptivity referred to famotidine has been found to be 2.0 x 104 L. mol-1cm. -1. The proposed method was applied successfully to the assay of famotidine in pharmaceutical preparation.
Highlights
Famotidine (FAM), 3-[[[2-[(Aminoiminomethyl) amino] – 4-thiazolyl] methyl] thio] -N-(aminosulfonyl) propanimidamide (Figure 1) (Molecular weight: 337.5 g.mol-1) [1], is a histamine H2-receptor antagonist (H2-RA)which competitively inhibits the action of histamine on the H2-receptors of parietal cells and thereby reduces the gastric acid secretion under daytime and nocturnal basal conditions
FMT is official in the British Pharmacopoeia [1] and in the United States Pharmacopoeia [2]
Various methods have been reported for the determination of famotidine as a pure drug and in pharmaceutical preparations
Summary
(aminosulfonyl) propanimidamide (Figure 1) (Molecular weight: 337.5 g.mol-1) [1], is a histamine H2-receptor antagonist (H2-RA). Which competitively inhibits the action of histamine on the H2-receptors of parietal cells and thereby reduces the gastric acid secretion under daytime and nocturnal basal conditions. It is widely used in the management of gastrointestinal disorders, such as aspiration syndrome, dyspepsia, gastro- oesophageal reflux disease, peptic ulcer and Zollinger-Ellison syndrome. Various methods have been reported for the determination of famotidine as a pure drug and in pharmaceutical preparations. These methods include titrimetric [3], spectrophotometric, [417] and HPLC [18-25]. The analytical procedure is simple, fast, accurate, and has been applied for the determination of famotidine in pure and pharmaceutical preparations
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