Abstract
The antischistosomal drug 1,5-di-(p-aminophenoxy)pentane (DAPP), an inhibitor of rhodopsin regeneration in the vertebrate retina, is shown to completely block the production of 11- cis-retinyl palmitate in the frog eye. An untreated frog generates a large amount of 11- cis-retinyl palmitate during 1–2 days in the dark after a strong bleach. Also, it is demonstrated that DAPP can deplete the stores of 11- cis-retinyl palmitate in the dark-adapted frog eye. The specificity of DAPP's inhibition of dark-adaptation is explored, and the usefulness of employing retinotoxic drugs to investigate the physiology and biochemistry of rhodopsin regeneration is discussed.
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