Abstract

For the investigation of the solvent selectivity in liquid solid chromatography, the mobilities of various steroidal pharmaceuticals were systematically measured using silica gel and alumina thin-layer chromatography (TLC). The parameters (ΔRM values) for the contribution of individual functional groups on the mobility were calculated by applying eleven solvent systems. The solvent selectivity was discussed on the basis of these values in relation to the structure of the steroids. For scaling the chromatographic systems examined by TLC to high performance liquid column chromatography (HPLC), their correlation in terms of mobility was extensively investigated. It was shown that the optimum system selected by TLC is applicable to HPLC with some minor modifications.

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