Abstract
Extensive genetic and biochemical analysis of mating-type gene silencing and a related, but metastable, form of repression near telomeres in yeast have led to a working molecular model (reviewed in ref. 4 and diagramed in Fig. 1). Mating-type gene silencer elements or telomeres act as cis initiation sites for the polymerization of SIR (silent information regulator) protein complexes onto neighboring nucleosomes. Silencers recruit SIR proteins through the combined …
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