The significance of vitamin D in mice with lupus nephritis

Abstract

Objectives To observe the changes of vitamin D level and disease related indicators and investigate the significance of vitamin D in immunity of regulating lupus nephritis(LN) by supplement of vitamin D in lupus nephritis mice. Methods A total of 64 lupus nephritis mice were randomly divided into A and B groups, mice both in A and B group were fed with normal feed and light, but the added intramuscular vitamin D to the mice of group B every day. Vitamin D level, 24-hour urinary protein, CRP, anti-ds-DNA antibody, C3 and C4 level were tested both in A and B group following 2~4 weeks of feeding. SPSS 13.0 was used to statistical analysis. Results ①After 2~4 weeks of feeding, vitamin D level of group B was higher than group A, the difference was statistically significance(P<0.05). ②The 24-hour urinary protein, CRP and anti-ds-DNA antibody of group B were lower than group A, but C3 and C4 level were higher than group A, the differences were statistically significance(P<0.05). Conclusions Supplement of vitamin D in lupus nephritis mice can reduce the 24-hour urinary protein, CRP, anti-ds-DNA antibody, and increase the C3 and C4 level, so vitamin D may play an important immunity role in LN. Key words: Lupus Nephritis; Vitamin D; Mice