The Significance of Primary Tumor Volume and Ebv on Survival and Recurrence in Pediatric Patients with Nasopharyngeal Carcinoma

Abstract

ABSTRACT Aim: Primary tumor volume (PTV) has been recognized as a promising prognostic indicator in the treatment of adult nasopharyngeal carcinoma (NPC). Our study was designed to analyze the value of the primary tumor volume [gross tumor volume of the primary site (GTV-P)] and EBV association in predicting the treatment outcome in pediatric patients with NPC treated with intensity modulated radiotherapy (IMRT). Methods: A retrospective review of 30 consecutive pediatric patients aged Results: The median PTV was 45.9ml. Large GTVprn (>55 ml) was associated with a significantly poorer local control, lower distant metastasis-free rate, and poorer survival. 3-year overall survival in the large tumor volume group (>55 ml) and the small tumor volume (≤ 55ml) were 58% and 100%, respectively (p = 0.007).The 3-year disease-free survival was 28% in the large tumor group and 94% in small tumor volume group (p = 0.002) while 3 year local recurrence-free survival in the large tumor group was 77% and 100% in the small tumor volume group (p = 0.02).The 3-year overall survival, disease-free survival, local control, and distant metastasis-free rates in all patients were 87%, 76%, 92%, and 76%, respectively. Conclusions: PTV had a close relationship with survival rates and recurrence rates in pediatric patients with NPC. The large tumor volume group (PTV > 55 ml) was associated with more recurrence and poor survival rate. Disclosure: All authors have declared no conflicts of interest.