2438: Relationship Between Primary Tumor Volume and Radiotherapeutic Outcome in Nasopharyngeal Carcinoma

Abstract

Purpose/Objective(s)To investigate the correlation of primary tumor volume of nasopharyngeal carcinoma with the clinical result of radiotherapy.Materials/MethodsOne hundred and fifty-four patients with nasopharyngeal carcinoma were treated with late-course accelerated hyperfractionated radiotherapy alone to a total dose of 78Gy/60Fx/6w. The primary tumor volume (PTV) was obtained by outlining the tumor contour on CT images, followed by the summation of area technique. The median follow-up time was 49.5 months. Kaplan Meier method was used to calculate survival and local control rates.ResultsEvident volume disparity with different T stage and the volume data overlap between continuous T stages was found. The mean primary tumor volume was as follows (cm3): T1 18.90(0.55∼59.33), T2 25.80(2.22∼80.64), T3 40.07(13.97∼87.97) and T4 56.04(19.18∼115.00). Univariant analysis showed that the poor 5-year local control, disease-free survival and distant relapse-free survival rates in patients with large tumor volume(>60cm3). Primary tumor volume was found to be an independent prognostic factor of local control in multivariant analysis without statistical significance to predict the disease-free survival or distant relapse-free survival rates.ConclusionsThe greater volume disparity with the same T stage and the data extension overlap with different T stage are demonstrated and the primary tumor volume may be considered as a prognostic factor in the treatment of nasopharyngeal carcinoma.Nasopharyngeal neoplasm, Radiotherapy, Computed tomography, Primary tumor volume. Purpose/Objective(s)To investigate the correlation of primary tumor volume of nasopharyngeal carcinoma with the clinical result of radiotherapy. To investigate the correlation of primary tumor volume of nasopharyngeal carcinoma with the clinical result of radiotherapy. Materials/MethodsOne hundred and fifty-four patients with nasopharyngeal carcinoma were treated with late-course accelerated hyperfractionated radiotherapy alone to a total dose of 78Gy/60Fx/6w. The primary tumor volume (PTV) was obtained by outlining the tumor contour on CT images, followed by the summation of area technique. The median follow-up time was 49.5 months. Kaplan Meier method was used to calculate survival and local control rates. One hundred and fifty-four patients with nasopharyngeal carcinoma were treated with late-course accelerated hyperfractionated radiotherapy alone to a total dose of 78Gy/60Fx/6w. The primary tumor volume (PTV) was obtained by outlining the tumor contour on CT images, followed by the summation of area technique. The median follow-up time was 49.5 months. Kaplan Meier method was used to calculate survival and local control rates. ResultsEvident volume disparity with different T stage and the volume data overlap between continuous T stages was found. The mean primary tumor volume was as follows (cm3): T1 18.90(0.55∼59.33), T2 25.80(2.22∼80.64), T3 40.07(13.97∼87.97) and T4 56.04(19.18∼115.00). Univariant analysis showed that the poor 5-year local control, disease-free survival and distant relapse-free survival rates in patients with large tumor volume(>60cm3). Primary tumor volume was found to be an independent prognostic factor of local control in multivariant analysis without statistical significance to predict the disease-free survival or distant relapse-free survival rates. Evident volume disparity with different T stage and the volume data overlap between continuous T stages was found. The mean primary tumor volume was as follows (cm3): T1 18.90(0.55∼59.33), T2 25.80(2.22∼80.64), T3 40.07(13.97∼87.97) and T4 56.04(19.18∼115.00). Univariant analysis showed that the poor 5-year local control, disease-free survival and distant relapse-free survival rates in patients with large tumor volume(>60cm3). Primary tumor volume was found to be an independent prognostic factor of local control in multivariant analysis without statistical significance to predict the disease-free survival or distant relapse-free survival rates. ConclusionsThe greater volume disparity with the same T stage and the data extension overlap with different T stage are demonstrated and the primary tumor volume may be considered as a prognostic factor in the treatment of nasopharyngeal carcinoma.Nasopharyngeal neoplasm, Radiotherapy, Computed tomography, Primary tumor volume. The greater volume disparity with the same T stage and the data extension overlap with different T stage are demonstrated and the primary tumor volume may be considered as a prognostic factor in the treatment of nasopharyngeal carcinoma.