Abstract
Antibiotics are essential in the prevention and treatment of bacterial infections, however, their misuse and overuse may lead to the development of antibiotic-resistant bacteria. In post-operative patients, selecting the appropriate antibiotics is crucial and should be based on factors such as the site of infection, causative organism, and pharmacokinetics of the antibiotics. Rational use of empirical antibiotics is critical in these cases and should be based on clinical indicators like a rise in total count and temperature spikes. To ensure the rational use of antibiotics, it is important to consider the time and duration of treatment, as well as the selection of antibiotics based on the specific patient and their medical history. Overall, the appropriate use of antibiotics is crucial in the prevention and treatment of bacterial infections, and healthcare professionals should prioritize rational prescribing practices to ensure the best outcomes for their patients while minimizing the risk of antibiotic resistance  
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