The short term effects of topical bromfenac sodium hydrate ophthalmic solution eye drops after SMILE

Abstract

Objective To compare the efficacy and ocular safety between bromfenac sodium hydrate ophthalmic solution eye drops and topical compound tobramycin eye drops for the treatment of postoperative inflammation and the effect on intraocular pressure in subjects who had undergone small incision lenticule extraction (SMILE).Methods In a prospective,case control study,30 patients (60 eyes) were treated with bromfenac sodium hydrate ophthalmic solution eye drops 2 times daily for 2 weeks,and 30 patients (60 eyes) were treated with topical compound tobramycin eye drops 4 times daily for 1 week.All subjects had undergone SMILE surgery for myopia correction.Visual quality,intraocular pressure (IOP),corneal sensitivity,tear film break up time (BUT),Schirmer's Ⅱ test,corneal fluorescein staining and ocular surface disease index (OSDI) were assessed preoperatively and at 1 week,1 month,and 3 months postoperatively.Comparisons of the variables were performed using the repeated measures analysis of variance and multiple comparison analysis with SPSS 19.0 statistical software.Results There was no significant difference between the group treated with bromfenac sodium hydrate ophthalmic solution eye drops and the group treated with compound tobramycin eye drops when uncorrected visual acuity,best corrected visual acuity,corneal sensitivity,BUT,Schirmer's Ⅱ test,corneal fluorescein staining and OSDI were compared.The IOPcc was significantly higher in the group treated with topical compound tobramycin eye drops (15.57±2.54 mmHg) compared to the group treated with bromfenac sodium hydrate ophthalmic solution eye drops (12.51±2.45 mmHg) and the difference was statistically significant (F=45.409,P＜0.05).Conclusion Bromfenac sodium hydrate ophthalmic solution eye drops have the same anti-inflammatory effect as topical compound tobramycin eye drops and do not significantly increase IOPcc during early recovery after SMILE surgery. Key words: Femtosecond laser; Small incision lenticule extraction; Anti-inflammatory dgents,non-steroidal; Corneal sensitivity; Tear film break-up time; Schirmer's Ⅱ test; Corneal staining