Meta-analysis of corneal sensitivity after femtosecond LASIK and SMILE surgery

Abstract

Objective To evaluate and compare corneal sensitivity after Femtosecond LASIK (FS-LASIK) and small incision lenticule extraction (SMILE) from a systematic review of literature.Methods This was a meta-analysis study.A systematic literature retrieval was conducted in Medline,the Cochrane Library,CBM disc,and CNKI.Central corneal sensitivity after FS-LASIK and SMILE was compared by meta-analysis,including pre-operation,1 week,1 month,3 months and 6 months post-operation.A statistical analysis was performed using RevMan 5.0 software.Weighted mean difference (WMD) (95％CI) was used to analyze continuous variables.The quality of the included literature was scored according to the Jadad scale.Results A total of 4 studies with a total of 198 patients (316 eyes) in the literature met the inclusion criteria Meta analysis results showed that there was no difference in central corneal sensitivity between FS-LASIK and SMILE before surgery (WMD=0.28,95％CI:-0.73～ 1.29,P＞0.05); however,1 week,1 month,3 months and 6 months after surgery,corneal sensitivity after SMILE was significantly higher than after FS-LASIK (WMD=-14.56,95％CI:-23.79～-5.34,P＜ 0.01; WMD=-15.29,95％CI:-22.46～-8.11,P＜0.01; WMD=-13.12,95％CI:-18.77～-7.46,P＜0.01;WMD=-3.45,95％CI:-5.72～-1.18,P＜0.01).Conclusion Compared with FS-LASIK,central corneal sensitivity after SMILE has a smaller decrease and faster recovery.Corneal sensitivity after SMILE is still higher than FS-LASIK during the 6-month period after surgery. Key words: Keratomileusis,laser in situ,femtosecond laser; Small incision lenticule extraction; Corneal sensitivity; Meta analysis; Evidence-based medicine