Abstract
Objective To investigate the relationship between serum uric acid level or hyperuricemia of healthy adults and gender, age, ethnicity and altitude in plateau area. Methods 17 358 healthy adults were randomly selected from Qinghai People′s Hospital Physical Examination Center from January 2016 to December 2016. We detected serum uric acid of these healthy controls and analyzed its relationship between gender, age and ethnicity. Besides, serum uric acid data of 7 596 healthy adults were collected to investigate its relationship between altitude. Those adults who were from different altitude areas were localized in Tibet. The serum uric acid was detected by Roche Modular DPP automatic biochemical analyzer. Results The serum uric acid of healthy adults who lived in Qinghai at 2 300 m above sea level generally formed a normal distribution. Serum uric acid of male and female was (371.14±69.33)μmol/L and (271.38±54.49) μmol/L respectively. Multivariate linear regression analysis showed that gender and ethnicity were the main factors which influence serum uric acid level at the same altitude(2 300 m). The serum uric acid levels and high uric acid detection rates between different genders and ethnicity at the same altitude were statistically significant. The serum uric acid levels and high uric acid detection rates of hyperuricemia among Tibetan healthy adult males at different altitudes were statistically significant. The simulated equation based on the elevation of serum uric acid and altitude difference was Y=0.041X+ 4.474(Y: the rise of serum uric acid, X: Bad altitude, R2=0.716). Conclusions Gender, ethnicity and altitude are the main factors influencing serum uric acid level and the high rate of hyperuricemia of healthy adult in Qinghai Plateau, among which, that of Tibetan are significantly higher than other ethnic groups. And serum uric acid levels increase along with altitude.(Chin J Lab Med, 2018, 41: 462-465) Key words: Hyperuricemia; Uric acid; Altitude
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