Correlation between serum uric acid and lipids in the adults with type 2 diabetes of different body mass indexes

Abstract

Objective To investigate the correlation between serum uric acid (UA) and lipids in the adults with type 2 diabetes mellitus (T2DM) of different body mass indexes (BMI). Methods A total of 284 adults with T2DM were selected. The general clinical data and laboratory examinations of all subjects were recorded, such as UA, serum lipids and other biochemical parameters. Patients were divided into four quartile groups according to the serum UA levels: group Q1, Q2, Q3 and Q4. The clinical data and biochemical characteristics were compared among all groups. All cases were divided into three groups according to BMI: normal group (18.5 kg/m2≤BMI<24.0 kg/m2); overweight group (24.0 kg/m2≤BMI<28.0 kg/m2); obesity group (BMI≥28.0 kg/m2). The correlation between UA and lipids was studied in each group. Results There were significant differences in the gender, age, triglyceride (TG), high density lipoprotein cholesterol (HDL-C), BMI, smoking history among UA quartile groups (P<0.05). The TG levels were higher, whereas HDL-C levels were lower among patients in group Q4 compared with other groups. Pearson correlation analysis showed that serum UA levels were significantly positive correlated with TG (r=0.314, P<0.001), and negative correlated with HDL-C (r=-0.276, P=0.002). The correlations between serum UA and lipids in BMI normal group and obesity group were not statistically significant. Multiple linear stepwise regression analysis showed that serum UA levels were independently positive correlated with TG (β=14.77, P=0.005) and negative correlated with HDL-C (β=-54.44, P=0.029). However, the UA levels in normal group and obesity group were not affected by serum lipids. Conclusions The correlation between serum UA and lipids in adult patients with T2DM was significantly affected by BMI. The control of serum lipids has a great meaning in decreasing the rate of hyperuricemia in overweight patients, but has little effect on the levels of UA in normal or obesity patients. Key words: Diabetes mellitus, type 2; Serum lipids; Uric acid; Body mass index