Abstract
ObjectiveTo investigate fetuin-A concentrations and its association with metabolic and sonographic cardiovascular markers in women with polycystic ovary syndrome (PCOS) and healthy subjects. Study designThirty-five women with PCOS and 37 healthy control women were matched for body mass index (BMI) and age. Serum fetuin-A concentrations, and reproductive and adrenal hormones were measured, and insulin resistance and carotid intima media thickness (CIMT) were evaluated in both groups. The correlations between cardiovascular risk factors, CIMT and fetuin-A concentrations were tested. ResultsMean fetuin-A concentrations were significantly elevated in the PCOS group compared with control subjects (101.2ng/ml±33.55 vs. 82.5ng/ml±32.65, P=0.019). CIMT was also higher in women with PCOS than in control subjects (0.51±0.05mm vs. 0.44±0.05mm, P<0.01). Serum lipid parameters were correlated to serum fetuin-A concentrations in the PCOS group, but no correlation was found between fetuin-A and CIMT (rPCOS=0.244, pPCOS=0.158; rcontrol=−0.002, pcontrol=0.988). ConclusionIn this, the first study of fetuin-A concentrations in PCOS, the results showed that fetuin-A concentrations were increased in euglycemic patients with PCOS.
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