Abstract
Summary The reaction of nucleic acids with certain antibacterial sera has been studied and the following points made: Nucleic acids give a specific precipitate with certain antisera, in particular equine antipneumococcic sera.The reactive substance is in the euglobulin fraction of the serum.The reaction is sensitive to changes in ionic strength. Also for a given ionic strength there is a difference in the amount of precipitate obtained when different ions are present.The reaction is specifically inhibited under suitable conditions by purine nucleotides, purine nucleosides and purine bases. Pyrimidine bases show only weak inhibition and pentoses and phosphates do not inhibit the reaction at all.
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