In Chapters 1 to 4, the factors that control selective complexation of metal ions were discussed. Here factors that control strength of metal-ligand interactions as these might relate to metal ions in biology are examined. It is not possible here to give an exhaustive account of selective complexation of metal ions in biology. Rather, factors that control selectivity are examined as they relate to selected examples in biology, and it is hoped that readers will be able to identify these same principles acting in their own area of interest in metal ions in biology.

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