Abstract
The administration of actinomycin D to fasted mice 12 hours before killing results in marked disaggregation of hepatic polyribosomes as determined by sucrose density gradients prepared from deoxycholate-treated postmitochondrial supernatants. This disaggregation of hepatic polyribosomes occurs in the free but not in the membrane-bound polyribosomes. Free, but not membrane-bound, polyribosomes of livers of actinomycin D-treated animals demonstrate decreased incorporation in vitro of 14C-leucine into proteins.
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