Abstract
Comparison of the partial sequences of the human βB 2-1- and βB 2-2-crystallin genes with orthologous rat or calf sequences shows that the fourth exon sequence of the human βB 2-2 gene contains a one triplet deletion and a mutated splice acceptor site. No transcripts from the βB 2-2-crystallin gene could be detected in the human lens. These data suggest that the human βB 2-2-crystallin gene is a pseudogene.
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