Abstract

Mitogen-activated protein (MAP) kinases are universal transducers of extracellular signals in all eukaryotes. Multiple MAPK pathways exist in each organism that are differentially activated by a variety of stimuli including chemical as well as physical factors. We have characterized the stress-activated MAP kinase (SAMK) pathway in plants that is involved in mediating touch, drought, cold, and wounding. The SAMK pathway is activated by a posttranslational mechanism, but inactivation requires de novo expression of gene(s). One of these genes isMP2C encoding a protein phosphatase type 2C that is able to inactivate the SAMK pathway.MP2C expression itself is regulated by the SAMK pathway and constitutes a negative feedback mechanism for resetting the pathway.

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