Abstract
In this study the effect of diazepam on some blood chemistry values was studied in male rats. Intraperitoneal administration of diazepam at a dose of 0.6mg/kg body weight for 60 days didn't induce significant changes in serum glucose, urea, cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, creatinine and alkaline phosphatase levels. Findings of this study give further sound for the safety of benzodiazepines.
Highlights
Diazepam was widely used in medical practice as antiepileptic, hypnotic, centrally acting muscle relaxant, tranquilizer and in treatment of alcohol withdrawal reaction [1]
In this study the effect of diazepam on some blood chemistry values was studied in male rats
Urea, total bilirubin, cholesterol, creatinine, alkaline phosphatase, AST, ALT was determined with the technicon SM A 12/60 system (Technicon Co., Domont, France)
Summary
Diazepam (a benzodiazepine) was widely used in medical practice as antiepileptic, hypnotic, centrally acting muscle relaxant, tranquilizer and in treatment of alcohol withdrawal reaction [1]. Many unwanted effects were associated with benzodiazepine therapy including drowsiness, ataxia, hypotension, blurred vision, incontinence and respiratory depression [2], and other unusual responses were recorded with benzodiazepines therapy including, nightmares, paradoxical delirium, confusion, depression, aggression and hostile behavior [3]. Hegarty and Dundee reported a significant incidence of painless thrombosis at injection site 7 to 10 days after intravenous diazepam administration, hematological, renal and hepatic toxicity have seldom been reported for benzodiazepines [3,4,5], a case of acute hepatic necrosis in doubtful relation to diazepam in-combination with other drugs has been recorded [6]
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