Abstract
Aim and objectives: Diabetes is a metabolic disorder with hyperglycemia due to defects in insulin secretion and function. Several studies investigated the both effects of traditional herbal medicine in diabetes treatment. Therefore, the aim of the present study was to investigate the effects of Morus Alba leaf Extracts (MAE) on hepatic enzyme activity in normal and streptozotocin-induced diabetic rats. Methods: Forty healthy adult male Wistar rats weighing 250 ± 10 gr were taken for this experiment. Rats were divided into 4 groups (10 rats in each group). Animals treated by a gavage tube for a period of two months as follow: group I: non diabetic control rats which only received distilled water; group II: non-diabetic rats that received (MAE) 1.0 g/kg per day; group III: diabetic control rats treated with distilled water and group IV: Diabetic rats which received MAE 1.0 g/kg per day. At the end of the 8th week, blood samples were collected and serum levels of enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and total bilirubin were measured in all study groups using commercial assay kits. The activity of two antioxidant enzymes including glutathione peroxidase (GPX) and glutathione reductase (GR) were also measured. Results: Findings of present study demonstrated that MAE significantly decreased serum levels of liver enzymes ALT, AST and ALP in diabetic rats in compare to the diabetic control groups while it increased GPX and GR activity(P<0.05). These results also indicated that MAE did not significantly affect LDH activity in diabetic rats treated with MAE in compared to the diabetic control groups. Conclusions: According to the present findings it could possibility be suggested that the anti-hyperglycemic effect of MAE is mediated at least partially by increasing liver GPX and GR activity as well as decrease serum levels of liver enzymes ALT, AST and ALP. These results are the other definite evidence supporting MA as traditional medicine for diabetic patients.
Highlights
According to the WHO reports, the diabetes mellitus (DM) will be the single largest non-communicable disease worldwide by the year 2025 with the largest diabetic population in India [1]
Animals treated by a gavage tube for a period of 56 days as follow: group I: non diabetic control rats which only received distilled water; group II: non-diabetic rats that received (MAE) 1.0 g/kg per day; group III: diabetic control rats treated with distilled water and group IV: Diabetic rats which received Morus Alba leaf Extracts (MAE) 1.0 g/kg per day
In the present study we examined the impacts of MAE on enzymes activity such as glutathione reductase (GR) and glutathione peroxidase (GPX) and serum levels of AST,ALT,alkaline phosphatase (ALP) and LD enzymes and BT and BD in diabetic male rats following a period of 56 days orally treatment
Summary
According to the WHO reports, the diabetes mellitus (DM) will be the single largest non-communicable disease worldwide by the year 2025 with the largest diabetic population in India [1]. One important strategy of the areas of research in diabetes treatment is reducing the amount of free radicals [8]. In this regard, the effects of antioxidants in preventing or reducing damage from free radicals in diabetes have been investigated [9]. Synthetic drugs in lowering blood glucose, are unable to control tissue damages in this disease but they can cause many side effects [6]. Plants that we know as herbal plant compounds are numerous These compounds together create a balanced situation and in this situation, none of the possessor compounds would have detrimental effects. Because they modify other properties and some compounds have the Received February 10, 2014; Accepted March 26, 2014; Published March 28, 2014
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