Abstract
BackgroundSeveral single nucleotide polymorphisms (SNPs) in lipid transport genes have been shown to be associated with premature coronary artery disease (PCAD). The scavenger receptor BI (SCARB1) is a key component of the reverse cholesterol transport and lipid metabolism. We aimed to examine the relationship between the rs5888 SNP within SCARB1and the risk of angiographically determined PCAD.MethodsWe used an age cut-off of 55 years for women and 45 years for men to define PCAD. Five-hundred and five patients with newly diagnosed angiographically documented PCAD (≥50 % luminal stenosis of any coronary vessel) as case group compared with 546 controls (subjects with no luminal stenosis at coronary arteries). The severity of CAD was determined by vessel score as well as Gensini score. A real-time polymerase chain reaction (PCR) and High Resolution Melting (HRM) analysis was used to distinguish between genotypes.ResultsT allele as compared to C allele was associated with increased odds of PCAD in total population (adjusted OR = 1.3, 95 % CI = 1.0 to 1.5; p = 0.020), and in women (adjusted OR = 1.3, 95 % CI = 1.0 to 1.8; p = 0.037), but not in men (adjusted OR = 1.2, 95 % CI = 0.9 to 1.5; p = 0.311). There was also no significant association between the examined polymorphism and the severity of CAD in whole or in men or women subgroups.ConclusionsOur findings suggest that the SNP (rs5888) within SCARB1 is independently associated with PCAD in a sex-dependent manner.
Highlights
Several single nucleotide polymorphisms (SNPs) in lipid transport genes have been shown to be associated with premature coronary artery disease (PCAD)
Wu et al [14] found that the individuals with TT genotype were associated with increased CAD risk, whereas others reported that the T allele or the T allele carrier was associated with decreased risk of CAD [15,16,17,18]
The women had a greater prevalence of hypertension, diabetes mellitus, and dyslipidemia as compared to men but cigarette smoking and opium addiction were much more frequent in men than in women
Summary
Several single nucleotide polymorphisms (SNPs) in lipid transport genes have been shown to be associated with premature coronary artery disease (PCAD). Scavenger receptor class B type (SCARB1, called SR-BI) is a multiligand cell surface receptor expresses both in macrophages and in the liver, indicating a major role for in the clearance of excess cholesterol from the body [10] This membrane protein facilitates the uptake of cholesteryl esters from high-density lipoprotein cholesterol (HDL-C) and drives cholesterol from tissues to the liver in the various stages of reverse cholesterol transport pathway. The aim of the present study was to examine the relation of rs5888 SNP with the presence and severity of angiographically determined PCAD in an Iranian coronary population
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