The roles of free radicals, peroxides and oxidized lipoproteins in second messenger system dysfunction.

Abstract

In living tissue, cells are constantly exposed to a wide variety of sources of oxidative stress under both physiologic and pathologic situations [1]. In most circumstances, the cell’s built-in defense mechanisms ensure that these stresses do not overwhelm the normal functioning of the cellular machinery [1]. In situations of acute or chronic stress or disease, however, these defense mechanisms may be overwhelmed or incapacitated. When this occurs, the cell may be destroyed, or its ability to properly function impaired, which in turn may lead to secondary disease processes.KeywordsCalcium TransientPhosphoinositide TurnoverCholesterol Ester HydroMessenger Signaling PathwayFree Radical InteractionThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.