Abstract
The Roles of Extracellular Purinergic Signaling in Local Acupoints In ChronoAcupuncture Analgesia
Highlights
Circadian rhythm was one of life characters
The pain threshold peaked at ZT0 and reached the bottom at ZT12 which entails time had a notable effect on pain threshold
Time had no obvious effect upon the pain threshold in model group (P=0.076,P>0.05)
Summary
Circadian rhythm was one of life characters. Peripheral clocks possessed by almost all cells [1]. Circadian clock encodes key regulators of response to therapeutic treatment [3]. Journal of Complementary Medicine & Alternative Healthcare the morning. Studies have shown that the change of pain threshold had obvious circadian rhythm [5,6]. It has been recognized that acupuncture, as an effective means of treatment, could relieve various kinds of pain syndromes [78]. The electro-acupuncture has regulation effects on circadian rhythm of temperature and melatonin in depression rat model [9]. In terms of chrono-acupuncture analgesia, the studies, pay more attention to central mechanism. Compared with the normal acupuncture, premature acupuncture for the regulation of dysmenorrhea model rats’ β-EP content and HSP70 expression in hypothalamus and pituitary more obvious effect. The peripheral mechanism of chrono-acupuncture analgesia, so far, poorly understood
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