Abstract
76 cases of ameloblastoma were investigated, the average age of the patients was 46 years. There were 49 (64.5%) cases of recurrence of the disease. Tissue antigens were determined using monoclonal rabbit antibodies to Ki-67 and β-catenin. it was found correlation between the proliferative activity of ameloblastoma cells and the intranuclear localization of β-catenin, indicating the activation of the Wnt/β-catenin-signaling pathway. It was shown that the nuclear localization of β-catenin is positively correlated with the recurrence. The Wnt/β-catenin signaling pathway is involved in a formation and progression of ameloblastoma.
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