Abstract
VPS13 proteins, whose dysfunction in humans underlies neurological disorders including Huntington‐like and early onset Parkinson’s diseases, are lipid transport protein active at membrane contact sites. VPS13 and proteins related by the presence of a chorein_N sequence, such as the autophagy protein ATG2, constitute a novel class of lipid transporters that solubilize tens of lipids within a wide hydrophobic channel. An intriguing possibility is that these proteins are bridges across which glycerolipids traverse the cytosol between membranes.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
