Abstract
VPS13 proteins, whose dysfunction in humans underlies neurological disorders including Huntington-like and early onset Parkinson's diseases, are lipid transport protein active at membrane contact sites. VPS13 and proteins related by the presence of a chorein_N sequence, such as the autophagy protein ATG2, constitute a novel class of lipid transporters that solubilize tens of lipids within a hydrophobic channel. An intriguing possibility is that these proteins are bridges across which glycerolipids traverse the cytosol between membranes.
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