THE ROLE OF VITAMIN D AS A NEW MARKER ON THE WOMEN INFERTILITY

Abstract

Cholecalciferol (Vitamin D) is essential to the proper functioning of the human body. This vitamin belongs to fat-soluble vitamins, responsible for stimulating the intestinal absorption of calcium and phosphate. It has been recently observed that vitamin D may be related to cases of female infertility. This study aimed to examine the effect of vitamin D on female infertility by analyzing hormonal and biochemical parameters. Estrogen, progesterone, FSH, LH, total Cholesterol, Triglyceride, HDL, LDL, VLDL, vitamin D, and BMI were tested in 60 women with infertility and 40 fertile women as a control group. The results showed a highly significant elevation in LH concentration, Triglyceride, LDL, and BMI in infertile women, compared to the healthy women at a significant P = 0.025, P = 0.01, P = 0.05, and P = 0.001, respectively. Also, a significant low elevation in the concentration of estrogen, progesterone, FSH, HDL, and vitamin D in infertile women when compared to the healthy women at a significant level of P = 0.01, P = 0.039, P = 0.05, P = 0.05, and P = 0.001, respectively was observed. This vitamin had a strong positive relationship with progesterone, FSH, total cholesterol, HDL, and LDL. It was also proved a significant inverse correlation to LH, estrogen, TG, VLDL, and BMI. It could be concluded that there is a significant decrease in the level of vitamin D in infertile women compared with the group of healthy women, especially with high BMI. It could also be deduced that vitamin D can be a new marker of increasing infertility and miscarriage risk.