THE ROLE OF VARIABILITY OF CANDIDATE GENES eNOS, MnSOD2, ADRB1 IN THE DEVELOPMENT OF CARDIOVASCULAR PATHOLOGY IN NEWBORN

Abstract

The study of gene polymorphism has been carried out to inform health care practitioners on genetic studies that can be used in clinical practice, and the genes under investigations aim at finding early manifestations of cardiovascular disorders. The possibility of determining the ways of correction of the detected cardiovascular pathology necessitates the prospect of further research starting from the neonatal period. To study the frequency of occurrence of genotypes of endothelial nitric oxide (eNOS) gene candidates polymorphism, mitochondrial superoxide dismutase (MnSOD2) 1 mutation and β1-adrenoreceptor (ADRB1) gene polymorphism in neonatal infants from perinatal risk groups the study involved examination of 186 newborns: 102 healthy full-term newborns, 25 newborns after asphyxia, 46 premature newborns and 13 newborns with intrauterine growth retardation. The study showed that the frequency of distribution of endothelial nitric oxide synthase (eNOS) C786T genotypes, mitochondrial superoxide dismutase (MnSOD2) T49C and β1-adrenergic receptor (ADRB1) Ser49Gly in newborns from perinatal risk groups in the neonatal period did not differ from healthy neonates.The CT genotype (p<0.05) of the endothelial nitric oxide synthase (eNOS) gene polymorphism C786T can be considered one of the predictors of cardiovascular development in newborns, which requires further clinical and instrumental comparison. Information on the prevalence of polymorphisms of genes associated with the development of cardiovascular events should be considered when developing a set of individual preventive measures.