Abstract
AbstractThis brief review describes the role of tissue-nonspecific alkaline phosphatase (TNAP) during dental development. Mutations within the ALPL gene, which is encoding the human ectoenzyme TNAP, lead to the rare disease Hypophosphatasia (HPP). Apart from the most prominent bone hypomineralization, the characteristic symptoms of HPP often include a dental phenotype. To investigate the molecular causes of distinct HPP symptoms in closer detail, a number of transgenic models in different animals are established, like mice (Mus musculus) and zebrafish (Danio rerio). We therefore also compare the processes of dental development in humans, mice, and zebrafish.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
