The role of thrombectomy and embolic protection devices

Abstract

In recent years, it has been demonstrated that restoration of normal coronary flow in the infarct-related artery is not equivalent to the restoration of myocardial perfusion through cardiac microcirculation. Among patients with ST-segment elevation myocardial infarction (STEMI) who undergo primary percutaneous coronary intervention (PCI), distal embolization and slow-flow and no-flow phenomenon occur in ∼30% of patients. In these patients, PCI results are less satisfactory, with lower thrombolysis in myocardial infarction (TIMI) or myocardial blush grade (MBG) values, lower rate of a complete resolution of ST-segment elevation, lower left ventricular ejection fraction, and poorer long-term outcome. Studies investigating the usefulness of thrombectomy systems in STEMI showed a similar proportion of patients with TIMI (flow grade 3) in the infarct-related artery in thrombectomy treated patients and control groups. Some small studies with thrombectomy systems or distal protection devices showed encouraging results with preventing slow-flow, no-reflow, and distal embolization, as measured by improved myocardial perfusion by angiography and improved ST-segment elevation resolution after PCI. Large, multi-centre studies did not confirm clinical benefit. New European Society of Cardiology PCI guidelines do not give definitive recommendations regarding the use of embolic protection devices for this group of patients. More randomized trials are needed. However, thrombectomy may be very effective in the situation of large thrombus bulk when present after first balloon catheter inflation. It could be also potentially effective with easy to use thrombectomy system for replacing balloon pre-dilatation before stenting, if studies could prove clinical benefit of such concept for primary PCI.