Abstract
Arterial hypertension and type 2 diabetes mellitus are the most widespread comorbid pathologies. The coexistence of these disorders accelerates the development of micro- and macrovascular complications, considerably increases the cardiovascular risk, as well as the risk of stroke and end stage renal disease. The synergism of these two pathologies is caused by the unity of pathogenetic mechanisms. Genetic predisposition also contributes to the development of both pathologies. It is well known that blockade of the renin-angiotensin system slows down the development of type 2 diabetes mellitus and also reduces the frequency of cardiovascular or kidney events in patients with these disorders. Gene polymorphisms of the reninangiotensin system are thoughtfully studied in the context of cardiovascular disease development. Currently, the role of gene polymorphisms in the development of carbohydrate disorders is not established, however, there is a high probability of their influence and importance. The purpose of review is to analyze the accumulated data on the effects of the renin-angiotensin system gene polymorphisms on the development of arterial hypertension and type 2 diabetes mellitus.
Highlights
Arterial hypertension and type 2 diabetes mellitus are the most widespread comorbid pathologies
The Siberian Medical Journal. 2019;34(3):33–39 angiotensin system are thoughtfully studied in the context of cardiovascular disease development
The role of gene polymorphisms in the development of carbohydrate disorders is not established, there is a high probability of their influence and importance
Summary
При изучении М235Т полиморфизма установлено, что вариант 235Т является независимым фактором риска развития инфаркта миокарда, ИБС. По данным других исследований, прослеживается связь ТТ генотипа полиморфизма М235Т гена AGT с большей вероятностью развития АГ, более высокими цифрами АД и более высоким уровнем концентрации АПФ [41, 42]. Association of angiotensin-converting enzyme I/D polymorphism with heart failure: a meta-analysis. Buraczyńska M., Pijanowski Z., Spasiewicz D., Nowicka T., Sodolski T., Widomska-Czekajska T. et al Renin-angiotensin system gene polymorphisms: assessment of the risk of coronary heart disease. Renin-angiotensin system gene polymorphisms: Potential mechanisms for their association with cardiovascular diseases. Association of angiotensinogen gene M235T and angiotensin-converting enzyme gene I/D polymorphisms with essential hypertension in Han Chinese population: a meta-analysis.
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