Abstract
The role of the nervous system in aging and longevity
Highlights
The lead review (Alcedo et al, 2013) in this collection of articles introduces different aspects of neuronal inputs and outputs of signaling pathways that affect homeostasis, and longevity and aging
Neuronal inputs are integrated by neural circuits, which can lead to longevity-modulating outputs
Because of the central role that calcium signaling plays in processing neural information, Nikoletopoulou and Tavernarakis (2012) highlight the importance of maintaining calcium homeostasis. They discuss how loss of calcium homeostasis increases the risk for neurodegenerative diseases and how aging itself can impair this homeostasis (Nikoletopoulou and Tavernarakis, 2012)
Summary
The lead review (Alcedo et al, 2013) in this collection of articles introduces different aspects of neuronal inputs and outputs of signaling pathways that affect homeostasis, and longevity and aging. These sensory cues likely modulate hypothalamic function and the neuroendocrine systems required for maintaining homeostasis [reviewed in Alcedo et al (2010, 2013); Jeong et al (2012)].
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