Abstract
Golgi is the main locus in mammalian cells for a number of enzymes involved in glycoprotein and glycolipid synthesis. Galactosyl- and sialyltransferases, which add terminal sugars to glycoproteins, are localized in Golgi in both liver and kidney. Galactosyltransferase can be solubilized using Triton X-100 and is probably an intrinsic membrane protein. Sulfo- and galactosyltransferases involved in the terminal steps of sulfatide and lactosylceramide synthesis are localized in kidney Golgi, while a sialyltransferase involved in ganglioside formation is localized in Golgi of both liver and kidney. In vivo, incorporation of 35 S-sulfate into sulfatide in the Golgi precedes that into sulfatide of plasma membranes in rat kidney, consistent with the view that sulfatide is synthesized first in the Golgi apparatus and then transferred to the plasma membrane.
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