Abstract
Annotation: Вackground. Atrial fibrillation increases the risk of death by 5 times. The search for new genetic markers of risk will make it possible to optimize the diagnosis and treatment of this disease. Purpose of the study. To identify the most significant molecular genetic markers of atrial fibrillation in combination with coronary heart disease in residents of the Siberian region. Materials and methods. The study included female and male patients diagnosed with coronary artery disease (IHD) and atrial fibrillation (AF) (n = 100) and a comparison group of 100 people with IHD without AF, in whom the frequencies of the rs10824026 genotypes of the SYNPO2L gene were studied for polymorphic variants. Results and conclusions. In the present study, we tested the association of rs10824026 of the SYNPO2L gene with atrial fibrillation in patients with coronary artery disease. It was found that the genotype GG rs10824026 manifests itself as conditionally protective in relation to the risk of developing AF in patients with coronary artery disease.
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