Abstract
The rate of oxidative demethylation of aminopyrine in the liver endoplasmic reticulum of male rats is inhibited by whole body irradiation (850 rad). It reaches a minimum on days 4–5 following irradiation when the V max is decreased and the K m markedly increased. Irradiation does not affect the lower rate of oxidative demethylation in female rats. Irradiation of the testis only with 1000 or 1500 rad also caused a decrease of V max and a large increase of K m for oxidative demethylation in the liver. Injection of testosterone following irradiation restores the K m and V max in male rats nearly to control values. Phenobarbitone injection following irradiation restores the K m for the oxidative demethylation to normal values and also causes a large increase in V max in both control and irradiated animals. Methyl cholanthrene injection following whole body irradiation does not affect the rate of oxidative demethylation of aminopyrine but increases the rate of hydroxylation of biphenyl to very high values equal to those observed after injection of unirradiated animals. It is considered that whole body irradiation does not affect the liver endoplasmic reticulum directly but inhibition ofoxidative demethylation is caused by an inhibition of the synthesis, or release of testosterone from the testes.
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