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Abstract
KNOTT, J. C. A., AND WILLS, E. D. Effects of Whole-Body Irradiation and Hormones on Drug Metabolism in the Liver Endoplasmic Reticulum. Radiat. Res. 53, 65-76 (1973). The rate of oxidative demethylation of aminopyrine by preparations of microsomes from male rat livers decreased following whole-body irradiation, reaching a minimum, of 25% of the control value, on the 4th and 5th days after 850 rads. Oxidative demethylation in preparations of microsomes from female rats or male or female mice was unaffected by this dose of irradiation. The decreased rate in male rats was caused mainly by an increase of the K. for the reaction from 0.52 to 1.60 mM. The rate of hydroxylation of biphenyl in the male rat liver was also depressed by whole-body irradiation to a similar extent as oxidative demethylation. Cytochrome P450 concentration in the microsomes was unaffected by irradiation, but NADPH cytochrome c reductase activity was depressed.
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