Abstract
Purpose Technetium-99m diethylene triamine pentaacetic acid (Tc-99m DTPA) renal dynamic scintigraphy is a widely used imaging technique that evaluates renal function of patients with extrarenal abnormalities, but its clinical value in potentially offering us information on proliferation of liposarcoma has not yet been reported. Methods We retrospectively reviewed 7 patients with histopathologically confirmed retroperitoneal liposarcoma who underwent Tc-99m DTPA renal dynamic scintigraphy. The clinical data, histopathological findings, Glomerular Filtration Rate (GFR), and Tc-99m DTPA uptake were recorded. Results Dedifferentiated liposarcoma and well-differentiated liposarcoma showed dissimilar degrees of Tc-99m DTPA uptake, an observation that correlated with Ki-67 expression (p < 0.01). 4 of the 7 patients were diagnosed with dedifferentiated liposarcoma, showing a moderate uptake of Tc-99m DTPA and greater than 20% Ki-67 expression on histological slides. Meanwhile, the remaining 3 patients, diagnosed with well-differentiated liposarcoma, showed no uptake of Tc-99m DTPA and Ki-67 expression of less than 5%. Conclusions This study suggests that Tc-99m DTPA renal dynamic scintigraphy provides diagnostic value in patients with retroperitoneal liposarcoma, not only in evaluating renal function but also in visualizing lesion-related radionuclide uptake, which may potentially offer further clinical insights into tumor proliferation and provide prognostic value for clinical outcomes in patients with retroperitoneal liposarcoma.
Highlights
Tc-99m diethylenetriaminepentaacetic acid (DTPA) undergoes glomerular filtration but neither renal tubular secretion nor reabsorption
Tc-99m DTPA renal dynamic scintigraphy becomes a useful tool for clinicians in assessing renal function, especially for patients with suspected renal impairment
Patient selection was based on the following inclusion criteria: (1) the patient underwent Tc-99m DTPA renal dynamic scintigraphy to assess the renal function; (2) liposarcoma was histopathologically confirmed; and (3) complete clinical data for the patients were available. e study contained 7 patients (5 female and 2 male patients; age range, 52–73 years; mean age, 59.6 years)
Summary
Tc-99m diethylenetriaminepentaacetic acid (DTPA) undergoes glomerular filtration but neither renal tubular secretion nor reabsorption. Tc-99m DTPA renal dynamic scintigraphy is valuable in examining extrarenal abnormalities through the uptake of radionuclide by lesions. Studies on the extrarenal uptake of Tc-99m DTPA have been limited to retroperitoneal abscesses [1], “phantom kidney” phenomena, and some tumors, including hypervascular tumors [2], aortic aneurysms [3], extramedullary plasmacytoma [4], and hepatic haemangioma [5]. Goshen et al [6] presented the use of Tc-99m DTPA renal scintigraphy to find palpable soft tissue tumors at any location in the body and noticed a chordoma through the uptake of Tc-99m DTPA. We noticed a phenomenon that well-differentiated liposarcoma and dedifferentiated liposarcoma have different degrees of uptake of Tc-99m DTPA in renal dynamic scintigraphy, which may provide us some information on the pathology of the tumor and we discuss here
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