Abstract
T cell immunoglobulin and mucin domain (TIM)-1 gene family mainly plays immune regulatory roles, including allergy, asthma, autoimmune diseases, transplant tolerance, the response to viral infections, and cancer. Recent studies have shown that TIM-1 is mainly expressed on several sorts of immune cells and tumor cells. TIM-1 was shown to be able to either promote or inhibit a variety of anti-tumor immune responses by binding to corresponding plasmic membrane ligands expressed by immune cells. Upregulation of TIM-1 might induce tumorigenesis in certain tissue cells. In this review, we attempted to describe various functions exerted by TIM-1 on different cell membranes, discuss their effects on tumorigenesis and tumor progression, and provide new ideas for cancer treatment. Key words: T cell immunoglobulin and mucin domain 1; Immune regulation; Tumor
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