The role of stimulus train length in mismatch negativity (MMN) abnormalities in schizophrenia: A comparison of the 'roving' and 'oddball' MMN paradigms

Abstract

Event Abstract Back to Event The role of stimulus train length in mismatch negativity (MMN) abnormalities in schizophrenia: A comparison of the 'roving' and 'oddball' MMN paradigms Sumie Leung1, Lisa-marie Greenwood1, Patricia Michie2, 3 and Rodney Croft4* 1 University of Wollongong, School of Psychology, Australia 2 University of Newcastle, School of Psychology and Priority Research Centre for Brain and Mental Health, Australia 3 Schizophrenia Research Institute, Australia 4 University of Wollongong, School of Psychology and Illawarra Health & Medical Research Institute, Australia Schizophrenia (SCZ) patients exhibit attenuated mismatch negativity (MMN) relative to controls. Although most MMN studies have employed an oddball paradigm, a 'roving' paradigm has also been used to assess memory trace formation in SCZ, with evidence suggesting that the build-up of this trace is important to the disorder. The aim of the present study was to determine whether this memory trace effect differs between controls and patients, and whether it is a better differentiator of group status than MMN from a traditional oddball paradigm. EEG data from 16 SCZ patients and 11 age- and sex-matched healthy controls were recorded during a roving (trains of 4, 8 or 24 standards, prior to a duration-deviant, where each train differed in frequency), and a multi-feature oddball paradigm (Standards - 50ms, 100Hz, 80dB; Duration deviant - 100ms; Frequency deviant - 1100Hz). Peak amplitudes were measured from MMN waveforms (roving and duration oddball only). Memory trace results were analysed with mixed design polynomial contrasts, and paradigm comparisons using mixed design simple contrasts (oddball vs linear; oddball vs quadratic). Roving MMN increased linearly (p=0.008) but not quadratically with train length (combined groups), and overall MMN was reduced in patients (p=0.028). However, the linear increase did not differ between the groups. A quadratic interaction was found (p=0.04), due to greater group differentiation for 8-train MMN. Relative to oddball MMN, no advantage was found in differentiating groups with the linear increase memory trace effect, whereas the quadratic change in MMN over train length was a better predictor of group status (p=0.011). These results suggest that train length is important in SCZ/MMN research, with the train length/MMN relation a better predictor of group status than oddball MMN. Further research is required to clarify the contributing factors to this finding, including the relative importance of standards and deviants to the relation. Keywords: Schizophrenia, MMN, mismatch negativity, Roving, Train length Conference: XII International Conference on Cognitive Neuroscience (ICON-XII), Brisbane, Queensland, Australia, 27 Jul - 31 Jul, 2014. Presentation Type: Poster Topic: Memory and Learning Citation: Leung S, Greenwood L, Michie P and Croft R (2015). The role of stimulus train length in mismatch negativity (MMN) abnormalities in schizophrenia: A comparison of the 'roving' and 'oddball' MMN paradigms. Conference Abstract: XII International Conference on Cognitive Neuroscience (ICON-XII). doi: 10.3389/conf.fnhum.2015.217.00153 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 19 Feb 2015; Published Online: 24 Apr 2015. * Correspondence: Prof. Rodney Croft, University of Wollongong, School of Psychology and Illawarra Health & Medical Research Institute, Wollongong, Australia, rcroft@uow.edu.au Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Sumie Leung Lisa-marie Greenwood Patricia Michie Rodney Croft Google Sumie Leung Lisa-marie Greenwood Patricia Michie Rodney Croft Google Scholar Sumie Leung Lisa-marie Greenwood Patricia Michie Rodney Croft PubMed Sumie Leung Lisa-marie Greenwood Patricia Michie Rodney Croft Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.